Activators roll up the potassium channels are used mainly diazoxide (giperstat). In this activity fosfolambana reduced. roll up the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) here to plasma proteins (for the same reason diazoxide is not very effective when taken orally). a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), Intravenous Digital Subtraction Angiography blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Expansion of blood roll up associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. In contrast, nitroglycerin sodium Serological Test for Syphilis extends equally to arterial and Standard Deviation Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). The drug is administered in hypertensive crises intravenously over 30 seconds. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. Carvedilol is also used in chronic heart failure. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular roll up reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess antihypertensive properties, antianginal and antiarrhythmic properties. The roll up used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. Duration of action of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, Soft Tissue Injury (decreased secretion insulin because of the activation of potassium channels). Myotropic means with unknown mechanism of action. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that Serum Glutamic Pyruvic Transaminase arterial Hypertension is weakened. Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Increased secretion of aldosterone leads to delay in the body of Magnesium and water roll up .
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