Side effects and complications in the use of drugs: extrapyramidal disorder, passage smooth muscle spasm disorders, skin itching, rash, hives, increase in plasma prolactin, very rarely - galactorrhoea, gynecomastia. soft 40 mg to 30 ml emulsion (40 mg / ml) Table. Method of production of drugs: Table. Contraindications to the use of drugs: allergy to the drug. 10 mg; Mr injection 0,5% to 2 sol., 10 mg / 2 ml to 2 ml amp. Pharmacotherapeutic group: A0ZFA-agents used in functional disorders of the alimentary canal. The main pharmaco-therapeutic action: the dopamine receptor antagonist such as D2, has antyholinesteraznu action, binding to receptors D2, dopamine inhibits the activity of ingredient muscle cells in adenilattsyklazy gastrointestinal tract, inhibits peristalsis of the stomach and intestines, does relax the lower esophageal sphincter, increases gastro-oesophageal and gastric reflux, duodeno, increases intragastric pressure, reduces blood levels of prolactin, blocking dopamine D2 receptors, itoprydu hydrochloride increases adenilattsyklazy activity in smooth muscle cells of gastrointestinal tract, therefore increasing the number of nucleotides and energy provision smooth muscle cells, which creates a basis for activation of motor activity and muscle tone gastrointestinal tract, due to antagonism D2 dopamine receptor antydopaminova action could occur in transient increase of ingredient prolactin, acetylcholine interacts ingredient the receptor protein (M3-receptor) in the membrane of smooth muscle cells, activates the receptor protein adenilattsyklaza internal receptor - protein kinase, which leads to fosforylyuvanya protein that causes increased permeability of the membrane to calcium, which stimulates smooth muscle of gastrointestinal tract ingredient . 10 mg 3 - 4 g / day for 15 - 30 minutes before meals, if necessary, before going to sleep but not more than 80 mg / day, children from 5 to 12 years - 0,25-0,5 mg / kg 3 - 4 g / day for 15 - 30 minutes before meals. Contraindications to the use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, intestinal obstruction, gastrointestinal tract perforation, pigment and prolaktonozalezhni tumors, phaeochromocytoma, epilepsy, glaucoma, extrapyramidal disorders, and trimester of pregnancy, lactation and children under 2 years. Side effects and complications in the use of drugs: diarrhea, the incidence ingredient nausea, dry mouth, constipation, depression cases, dyskinetychnoho c-mu ingredient galvanic movements, particularly in ingredient head, neck and shoulder), rare cases parkinsonizmu (Tremor, rigidity of muscle, akineziya) Angiotensin-Converting Enzyme piznya dyskineziya; rare phenomenon: cases of malignant neuroleptic with th (Typical ingredient fever, muscle rigidity, altered consciousness and blood pressure fluctuations), fatigue, drowsiness, Chief pain, dizziness, No Abnormality Detected anxiety, ingredient of skin rashes, hives, itchy skin and hyperemia, angioedema; methemohlobinemiyi cases, hyperprolactinaemia, hinekomastiya, galactorrhoea or breach menstruatsiy. chewing on 80 mg, 125 mg. ingredient oral use 30 ml (40 mg / ml) in vials, cap. Method of production of drugs: Table., Film-coated, 10 mg tab.
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