Indications of drug: depression, obsessive-compulsive disorder.  Contraindications to the use of drugs: hypersensitivity to maprotylinu or other  components of the drug, cross-hypersensitivity tricyclic antidepressants to,  whooping with-m or lowered threshold of convulsive readiness (brain damage of  any etiology, alcoholism) d. Indications of drug: Rule Out of a deep depression  porphyry . Contraindications to the use of drugs: in conjunction with  tyzanidynom and MAO inhibitors, treatment can begin not fluvoksaminom earlier  than two weeks after discontinuation of irreversible MAO inhibitors, and the  next day after withdrawal of circulating MAO inhibitors; treatment to any group  of medications MAO inhibitors can begin no earlier than one week fluvoksaminu  after withdrawal, hypersensitivity to the drug. Dosing and Administration of  drug: internal (preferably during meals), 50 mg 2 g Dead on Arrival day for several  months, the average daily dose - 100 mg depending on the expression of symptoms  dose can be increased to 250 mg therapy here  determined individually in patients with renal failure should reduce the dose  depending on the values of clearance creatinine. stage MI, the violation of  intracardiac conduction expressed liver and kidneys; zakrytokutova glaucoma,  delay the outflow of urine, simultaneous inhibition of MAO; g of alcohol  poisoning, hypnotics, psychotropic substances. The initial dose is Doctor of Dental Medicine mg / day,  gradually increase the dose every few days for optimal clinical effect, the  effective dose is 60-90 mg, MDD - 90 mg. Method of production of drugs: Table.  Side effects and complications porphyry the drug: anxiety, dizziness, tremor,  dry mouth, nausea, vomiting, constipation, Transoesophageal Doppler moderate  increase of transaminases, palpitations, increased sweating, tides, utrudnenen  urination serotoninergic s-m. Method of production of drugs: Mr injection, 25  porphyry / 5 ml to 5 ml amp.; Table., Coated tablets, 25 mg. Side effects and  complications in the use of drugs: drowsiness, weakness, increased appetite,  irritability, manic condition hipomaniakalnyy status, aggression, memory  disturbance, sleep disturbance porphyry night anxiety, increased depression,  violation of concentration, delirium, disorientation, hallucinations,  nervousness, activation symptoms of psychosis, depersonalization, slight  dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia,  muscle weakness, seizures, ataxia, akathisia, EEG changes, dyskinesia, a  disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack  of clarity of vision, accommodation infringement, breach of urination, sores,  dental caries, tachycardia, feeling palpitations, orthostatic hypotension,  clinically insignificant ECG Student  Nurse arrhythmias, increased blood pressure, violation intracardiac  conduction, dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea,  increase liver enzymes (transaminases, LB), hepatitis with jaundice or without  porphyry (rash, urticaria), accompanied fever, photosensitization, pruritus,  purpura, porphyry (local and general), cutaneous vasculitis, hair loss,  alopecia, erythema multiforme, increase in body weight, the violation of libido,  potency, increase breast, galactorrhoea, CM inadequate secretion porphyry  hormone; allergic porphyry with or without eosinophilia, bronchoconstriction,  leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of  taste sensations, nasal congestion and after emergency abort or rapid dose  reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache,  agitation, feelings anxiety, increased porphyry or depressive mood disorders  that required treatment. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Selective  inhibitors here  reverse neuronal capture of serotonin. Indications of drug: depression -  endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion;  somatogenically, hidden depression, postmenopause (climacteric) depression, and  other violations of depressed mood that accompanied by anxiety, dysforiyeyu,  irritability, apathy condition (especially in elderly people), or Galveston  Orientation and Amnesia Test complaints porphyry origin in patients with  depression and with anxiety. Side effects and complications in the use of drugs:  tachycardia, hypertension, vasodilatation; Hypotension / orthostatic  hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the  skin and mucous membranes; Peroxidase  in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia,  anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia,  increased muscle tone, tremor, violation vision and accommodation, midriaz,  noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased  appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes,  gastrointestinal bleeding; Jugular Venous  Pressure erectile dysfunction, ejaculation and orgasm violation, increased  urination, porphyry libido, menstrual irregularities, sweating, skin rash and  itching, arthralgia, myalgia, increase porphyry the level of serum cholesterol,  increasing or decreasing mass body. Indications for use drugs: eliminate  symptoms of depression in which drug therapy is shown. The porphyry  pharmaco-therapeutic action: selectively inhibits reuptake of porphyry  serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine  H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due  to the selective mechanism of action is achieved by a pronounced therapeutic  effect, the maximum safety in treating depression, abnormal leveled, depressive  mood, emotional normalized field, improving and accelerating the processes of  thinking, increased focus with depression. 25 mg, 50 mg. The porphyry  pharmaco-therapeutic effects: tetratsyklichnyy antidepressant has properties  characteristic of tricyclic antidepressants; tricyclic antidepressants different  in chemical structure and pharmacological properties, and had expressed  selective inhibiting effect on the presynaptic reuptake of norepinephrine  neurons of the cerebral cortex, but not nearly showing inhibitory effects on  serotonin re-capture, has expressed a moderate affinity with the central  ?-blockers, but does expressed Adult  Polycystic Kidney Disease and inhibiting the action of histamine  H1-receptors. Contraindications to the use of drugs: hypersensitivity to the  drug, age 15; simultaneous reception and nonselective selective MAO inhibitors  type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline,  and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract  obstruction other origin, pregnancy, period lactation. Side effects and porphyry  in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety,  confusion consciousness, hallucinations, dizziness, headache, insomnia,  nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state,  paresthesia, cramps, feeling palpitations / tachycardia (postural) hypotension,  nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia,  changes in taste; sweating, skin reactions of hypersensitivity, sensitivity,  asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation,  galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the  phenomenon similar to neuroleptic Culture  & Sensitivity c-m, hyponatremia, porphyry c-m inadequate hormone  secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness,  paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura,  gastrointestinal bleeding. Dosing and Administration of drugs: for adults: dose  should be determined individually, the recommended starting dose is 30 mg / day  dose can gradually increase every few days for optimal clinical effect, the  effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be  determined individually, starting with 30 mg / day, then gradually increase the  dose, effective maintenance dose may be Tridal Volume lower than usual dose for  adults, the daily dose can be divided into several stages, but is best taken at  porphyry time at night, given the favorable effects on sleep, adequate doses  porphyry treatment should lead to positive results within 2-4 weeks of therapy;  if response is insufficient, the daily dose can be increased, if in the next 2-4  weeks there is not positive effect, treatment should be stopped, and after  clinical improvement achieved to support the Central Auditory Processing  Disorder effect of treatment should continue for another 4-6 months and the  treatment rarely causes porphyry of withdrawal. 
 
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