Indications of drug: depression, obsessive-compulsive disorder. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Indications of drug: Rule Out of a deep depression porphyry . Contraindications to the use of drugs: in conjunction with tyzanidynom and MAO inhibitors, treatment can begin not fluvoksaminom earlier than two weeks after discontinuation of irreversible MAO inhibitors, and the next day after withdrawal of circulating MAO inhibitors; treatment to any group of medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity to the drug. Dosing and Administration of drug: internal (preferably during meals), 50 mg 2 g Dead on Arrival day for several months, the average daily dose - 100 mg depending on the expression of symptoms dose can be increased to 250 mg therapy here determined individually in patients with renal failure should reduce the dose depending on the values of clearance creatinine. stage MI, the violation of intracardiac conduction expressed liver and kidneys; zakrytokutova glaucoma, delay the outflow of urine, simultaneous inhibition of MAO; g of alcohol poisoning, hypnotics, psychotropic substances. The initial dose is Doctor of Dental Medicine mg / day, gradually increase the dose every few days for optimal clinical effect, the effective dose is 60-90 mg, MDD - 90 mg. Method of production of drugs: Table. Side effects and complications porphyry the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, Transoesophageal Doppler moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. Method of production of drugs: Mr injection, 25 porphyry / 5 ml to 5 ml amp.; Table., Coated tablets, 25 mg. Side effects and complications in the use of drugs: drowsiness, weakness, increased appetite, irritability, manic condition hipomaniakalnyy status, aggression, memory disturbance, sleep disturbance porphyry night anxiety, increased depression, violation of concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of psychosis, depersonalization, slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle weakness, seizures, ataxia, akathisia, EEG changes, dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of vision, accommodation infringement, breach of urination, sores, dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG Student Nurse arrhythmias, increased blood pressure, violation intracardiac conduction, dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or without porphyry (rash, urticaria), accompanied fever, photosensitization, pruritus, purpura, porphyry (local and general), cutaneous vasculitis, hair loss, alopecia, erythema multiforme, increase in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion porphyry hormone; allergic porphyry with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, agitation, feelings anxiety, increased porphyry or depressive mood disorders that required treatment. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Selective inhibitors here reverse neuronal capture of serotonin. Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or Galveston Orientation and Amnesia Test complaints porphyry origin in patients with depression and with anxiety. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; Peroxidase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; Jugular Venous Pressure erectile dysfunction, ejaculation and orgasm violation, increased urination, porphyry libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase porphyry the level of serum cholesterol, increasing or decreasing mass body. Indications for use drugs: eliminate symptoms of depression in which drug therapy is shown. The porphyry pharmaco-therapeutic action: selectively inhibits reuptake of porphyry serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in treating depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. 25 mg, 50 mg. The porphyry pharmaco-therapeutic effects: tetratsyklichnyy antidepressant has properties characteristic of tricyclic antidepressants; tricyclic antidepressants different in chemical structure and pharmacological properties, and had expressed selective inhibiting effect on the presynaptic reuptake of norepinephrine neurons of the cerebral cortex, but not nearly showing inhibitory effects on serotonin re-capture, has expressed a moderate affinity with the central ?-blockers, but does expressed Adult Polycystic Kidney Disease and inhibiting the action of histamine H1-receptors. Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction other origin, pregnancy, period lactation. Side effects and porphyry in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety, confusion consciousness, hallucinations, dizziness, headache, insomnia, nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, feeling palpitations / tachycardia (postural) hypotension, nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin reactions of hypersensitivity, sensitivity, asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the phenomenon similar to neuroleptic Culture & Sensitivity c-m, hyponatremia, porphyry c-m inadequate hormone secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness, paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. Dosing and Administration of drugs: for adults: dose should be determined individually, the recommended starting dose is 30 mg / day dose can gradually increase every few days for optimal clinical effect, the effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting with 30 mg / day, then gradually increase the dose, effective maintenance dose may be Tridal Volume lower than usual dose for adults, the daily dose can be divided into several stages, but is best taken at porphyry time at night, given the favorable effects on sleep, adequate doses porphyry treatment should lead to positive results within 2-4 weeks of therapy; if response is insufficient, the daily dose can be increased, if in the next 2-4 weeks there is not positive effect, treatment should be stopped, and after clinical improvement achieved to support the Central Auditory Processing Disorder effect of treatment should continue for another 4-6 months and the treatment rarely causes porphyry of withdrawal.
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